Description
Rosuvastatin instructions for use
- Familial homozygous hypercholesterolemia as an adjunct to diet and other lipid-lowering therapy (eg, LDL apheresis), or when such therapy is insufficiently effective.
- hypertriglyceridemia (type IV according to the Fredrickson classification) as an adjunct to diet; to slow the progression of atherosclerosis as an adjunct to diet in patients who are indicated for therapy to reduce total and LDL-C concentrations;
Rosuvastatin method of administration and dosage
Orally, do not chew or break, swallow whole with water. The drug can be administered at any time of the day, regardless of meal time. Before starting therapy with Rosuvastatin, the patient should begin to follow a standard hypocholesterolemic diet and continue to follow it during treatment.
ROSUVASTATIN FT should be taken once a day. The tablet should be swallowed whole, without chewing and with water. ROSUVASTATIN FT can be taken at any time of the day, regardless of meals. It is advisable to take the tablet at the same time every day.
Rosuvastatin special instructions for use
Renal effects
Tubular proteinuria has been observed in patients receiving high doses of rosuvastatin (mostly 40 mg), but in most cases it was transient. Such proteinuria does not indicate acute kidney injury or progression of kidney disease. In patients receiving the drug at a dose of 40 mg, it is recommended to monitor renal function during treatment.
Determination of creatine phosphokinase activity
Determination of CPK activity should not be performed after intense physical exertion or in the presence of other possible causes of increased CPK activity, which may lead to incorrect interpretation of the results. If the initial CPK activity is significantly elevated (5 times higher than the upper limit of normal), a repeat measurement should be performed after 5-7 days. Do not initiate therapy if the repeat test confirms the initial CPK activity (higher than 5 times compared to the upper limit of normal).
Liver
It is recommended to determine liver function parameters before the start of therapy and 3 months after the start of therapy. Rosuvastatin should be discontinued or the dose should be reduced if the activity of “liver” transaminases in the blood serum is 3 times higher than the upper limit of normal.
In patients with hypercholesterolemia due to hypothyroidism or nephrotic syndrome, treatment of the underlying disease should be initiated before initiating treatment with Rosuvastatin
Rosuvastatin tablets instructions and dosages
Orally, do not chew or crush the tablet, swallow whole with water. The drug can be prescribed at any time of the day, regardless of meal time.
Before initiating therapy with Rosuvastatin, the patient should begin a standard cholesterol-lowering diet and continue it during treatment. The dose of the drug should be individualized depending on the goals of therapy and the therapeutic response to treatment, taking into account current recommendations for target lipid concentrations.
rosuvastatin 5 mg instructions
The recommended starting dose for patients starting treatment with rosuvastatin or for patients transferred from other HMG-CoA reductase inhibitors is 5 mg or 10 mg rosuvastatin once daily. The initial dose should be based on individual cholesterol levels and the potential risk of cardiovascular complications, as well as the potential risk of side effects. If necessary, the dose can be increased to a higher dose after 4 weeks.
rosuvastatin 10 mg instructions
For children aged 6-9 years with heterozygous familial hypercholesterolemia, the recommended dose is 5-10 mg orally once daily. The safety and efficacy of rosuvastatin doses greater than 10 mg have not been studied in this population.
